Development And Standardization Of Novel Herbal Formula For The Management Of Liver Disease

Abstract

Ethanomedicinal plant like Gymnosporia montana belonging to the family Celeastraceae commonly known as Vikalo in Gujarat.Ethanomedicinally fresh leaves of Vikalo are chewed in trible regions of Gujarat to cure jaundice. To develop drugs from these newsources, additional work is required for preclinical and clinical results. Since ancient times, different plant part extracts have beenused as traditional medicines against liver diseases. This knowledge may be useful in developing future powerful drugs. The presentstudy deals with the development of novel herbal formula comprising of the Hydro-alcoholic (70%) extract of Gymnosporiamontana. The Preformulation parameters and parameters for finished product (hard gelatin capsule) include uniformity of weight,disintegration time, moisture content, pH, phytochemical estimation were performed. Hepatoprotective activity of the finishedproduct was performed By MTT assay against HepG2 cell line. The prepared novel herbal formula showed significanthepatoprotective activity against HepG2 cell line.

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