Recent Advanced Approaches in Protein and Peptide Drug Delivery System: A Review

Abstract

Protein and Peptide drug delivery system are the Novel drug Delivery System. Proteins and peptides are the most abundant components of biological cells. They exist functioning such as enzymes, hormones, structural element and immunoglobulin. The twenty different naturally occurring amino acids join with each other by peptide bonds and build polymers referred to peptides and proteins. Although the distinction between peptides and proteins are peptide contains less than 20 amino acids, having a molecular weight less than 5000, while a protein possesses 50 or more amino acids and its molecular weight lies abovethis value. The most of pharmaceutical proteins and peptides areabsorbed IM, IV and Subcutaneous route of Absorption, but the oralroute is more convenient for absorption ofprotein as compared toother. Various problems associated with administration of protein andpeptide drugs are needed to overcome by different pharmaceutical approaches. Severalapproaches available for maximizing pharmacokinetic and pharmacodynamics properties arechemical modification, formulation vehicles, mucoadhesive polymeric system, use of enzymeinhibitors, absorption enhancers, penetration enhancers etc. The Present Review is describedStructure, classification of Protein, Need, Advantages, Function of protein and peptide drugdelivery system. Route of Absorption, Pharmaceutical approaches, Incorporation of DDS,Stability aspect, Applications, Recent Advances and Marketed formulation of Protein andPeptide drug delivery system.